Ketohexokinase inhibition improves NASH by reducing fructose-induced steatosis and fibrogenesis

Emma L Shepherd,Raquel Saborano,Ellie Northall, Kae Matsuda,Hitomi Ogino,Hiroaki Yashiro,Jason Pickens,Ryan E Feaver,Banumathi K Cole,Stephen A Hoang,Mark J Lawson,Matthew Olson,Robert A Figler,John E Reardon,Nobuhiro Nishigaki,Brian R Wamhoff,Ulrich L Günther,Gideon Hirschfield,Derek M Erion,Patricia F Lalor

JHEP Reports（2021）

引用 32|浏览10

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摘要

•Mice deficient in ketohexokinase (KHK) show reduced features of NASH on a high-fat/high-fructose diet.•KHK inhibition reduces lipogenic gene expression in the presence of high fructose/glucose.•Activated myofibroblasts show reduced expression of fibrogenic genes when treated with KHK inhibitor.•KHK inhibitor reduced hepatic accumulation of lipogenic fructose derivatives and glycolysis in human liver.

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关键词

NAFLD,Metabolism,Fructose,Fibrosis,Treatment,NASH

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