Previous liver regeneration induces fibro-protective mechanisms during thioacetamide-induced chronic liver injury

•The murine thioacetamide (TAA) model mimics histopathological features of chronic human liver disease and leads to hepatocellular carcinoma if administered long-term.•TAA-induced chronic liver injury, followed by a recovery period, creates a microenvironment that reduces fibrotic disease progression during a second round of TAA toxicity.•Co-culture of hepatic stellate cells (HSCs), with the well-characterised LPC line BMOL leads to the regulation of fibrosis-associated factors in the HSCs.•Or novel data propose a regulatory role of LPCs during chronic liver injury, mediated by cellular communication.