A Novel Transdermal Application for Clearing Skin Colonization by Candida auris

Candida auris has demonstrated the ability to colonize the skin of hospitalized patients, possibly contributing to nosocomial spread. The objective of this study was to determine whether two novel transdermal agents could clear skin colonization established by C. auris. A murine skin colonization model was first optimized and then used to test fungal burden reduction following treatment with 1% terbinafine or 1% clotrimazole in a proprietary Advanced Penetration Technology formulation (APT). Both treatments significantly reduced fungal burden compared to that in control groups. These novel agents show promise as a topical means of preventing skin colonization by C. auris.