Learning Poly-Synaptic Paths With Traveling Waves

Author summaryThere are approximately 10(11) neurons with 10(14) connections in the human brain. Information transmission among neurons in this large network is considered crucial for our behavior. To achieve this, multiple synaptic connections along a poly-synaptic network path must be adjusted coherently during learning. Because the previously proposed reward-dependent synaptic plasticity rule requires coactivation of presynaptic and postsynaptic neurons, learning can fail if a subset of neurons along a distant network path is inactive at the beginning of learning. We suggest that traveling waves that are initiated at an information source can mitigate this problem. We performed computer simulations of spiking neural networks with reward-dependent local synaptic plasticity rules and traveling waves. Our results show that this combination facilitates the learning and refinement of synaptic network paths. We argue that these features are a general biological strategy for maintaining and optimizing our brain function. Our research provides new insights into how complex neural networks in the brain form during learning and memory consolidation.Traveling waves are commonly observed across the brain. While previous studies have suggested the role of traveling waves in learning, the mechanism remains unclear. We adopted a computational approach to investigate the effect of traveling waves on synaptic plasticity. Our results indicate that traveling waves facilitate the learning of poly-synaptic network paths when combined with a reward-dependent local synaptic plasticity rule. We also demonstrate that traveling waves expedite finding the shortest paths and learning nonlinear input/output mapping, such as exclusive or (XOR) function.