Toward improving androgen receptor-targeted therapies in male-dominant hepatocellular carcinoma

Hong Zhang,Kristen Spencer,Stephen K. Burley, X.F. Steven Zheng

Drug Discovery Today（2021）

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摘要

•AR is an oncogenic driver of hepatocellular carcinoma.•AR-targeted therapy is limited by feedback activation of AKT-mTOR pathway.•Co-targeting of mTORC1 and AR may be an effective approach to HCC treatment.

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