High levels of interleukin-6 in rheumatoid arthritis joint fluids can stimulate local production of C-reactive protein resulting in elevated circulating levels

Johan Rönnelid,Ann Knight, Jörgen Lysholm,Vivek Anand Manivel,Azita Sohrabian,Anders Larsson,Tomas Weitoft

Joint Bone Spine（2021）

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摘要

•Locally produced IL-6 may stimulate CRP production in joints of anti-CCP2 positive RA patients.•This might partly explain circulating CRP levels.•Serum CRP levels might not only be a marker of systemic inflammation in RA.

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关键词

Rheumatoid arthritis,C-reactive protein,Interleukin-6,Synovial fluid

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