Astragaloside IV ameliorates steroid-induced osteonecrosis of the femoral head by repolarizing the phenotype of pro-inflammatory macrophages

Chaolai Jiang,Zubin Zhou,Yiwei Lin,Haojie Shan,Wenyang Xia,Fuli Yin,Nan Wang,Lihui Zhou,Youshui Gao,Xiaowei Yu

International Immunopharmacology（2021）

引用 16|浏览14

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摘要

•AS-IV repolarizes macrophages from M1 to M2 phenotypes.•Culture medium from AS-IV treated M1 macrophages suppresses cell apoptosis.•AS-IV decreases the ratio of M1 macrophages in the femoral head.

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关键词

Astragaloside IV,Osteonecrosis of the femoral head,Macrophages,Repolarization,Inflammation

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