Truncation of 3′ CCND1 by t(11;22) leads to negative SP4 CCND1 immunohistochemistry in blastoid mantle cell lymphoma

Fumiyo Maekawa,Chiyuki Kishimori,Miho Nakagawa,Kayo Takeoka,Katsuhiro Fukutsuka,Masahiko Hayashida,Futoshi Iioka,Masakazu Fujimoto,Kengo Takeuchi,Hirokazu Nakamine,Hitoshi Ohno

Blood Advances（2021）

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摘要

t(11;22)(q13;q11)/CCND1-IGL resulted in truncation of the CCND1 3′ coding sequences in a case of blastoid variant mantle cell lymphoma. The translocation generated CCND1 with a C-terminal alteration, leading to negative CCND1 immunohistochemistry by SP4 monoclonal antibody.

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关键词

blastoid mantle cell lymphoma,negative sp4 ccnd1 immunohistochemistry

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