Mechanisms of context conditioning in the developing rat

Mark E Stanton,Nathen J Murawski,Sarah A Jablonski,Patrese A Robinson-Drummer,Nicholas A Heroux

Neurobiology of Learning and Memory（2021）

引用 4|浏览15

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摘要

•The context preexposure facilitation effect (CPFE) develops between PD17 and 24.•Retention or retrieval, but not incidental learning, of contexts change across age.•Context-elicited IEG expression, in mPFC, dHPC, and amygdala, changes with age.•Disrupting prefrontal-hippocampal plasticity abolishes the CPFE in PD24-31 rats.•PD4-9 alcohol impairs the CPFE via reduced context-elicited IEG expression in mPFC.

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关键词

Spatial learning,Hippocampus,Prefrontal cortex,Immediate early gene,Fetal alcohol syndrome,Ontogeny,Memory systems

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