A novel ocular function for decorin in the aqueous humor outflow

Magdalena Schneider,Ramona Pawlak,Gregor R. Weber,Andrea E. Dillinger,Sabrina Kuespert,Renato V. Iozzo,Harry A. Quigley,Andreas Ohlmann,Ernst R. Tamm,Rudolf Fuchshofer

Matrix Biology（2021）

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摘要

•Decorin deficiency leads to elevated intraocular pressure in mice.•TGF-β target genes are enriched in the conventional outflow pathways of decorin-deficient mice.•Decorin attenuates the expression of TGF-β2 in cultured HTM cells.•Decorin levels are reduced in the chamber angle of glaucomatous eyes.

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关键词

Glaucoma,Decorin,TGF-β,Extracellular matrix,Intraocular pressure,Trabecular meshwork

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