The Complement Pathway is Activated in People with Human Immunodeficiency Virus and is Associated with Non-AIDS Comorbidities.

Ivan Vujkovic-Cvijin,Ornella Sortino,Eveline Verheij,Ferdinand W. Wit,Neeltje A. Kootstra,Brian Sellers,Maarten Schim van der Loeff,Yasmine Belkaid,Peter Reiss,Irini Sereti

The journal of infectious diseases (Online University of Chicago Press)/The Journal of infectious diseases（2021）

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摘要

Unbiased plasma proteomics in a matched case-control study of treated people with human immunodeficiency virus (PWH) revealed the complement cascade as being among the top pathways enriched in PWH. Specific complement components, namely C5, associated significantly with non-AIDS comorbidity prevalence, and did so more strongly than previously established predictive biomarkers.

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关键词

HIV,comorbidities,complement,noncommunicable diseases,biomarker

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