Temporal lobe dysfunction in late-onset epilepsy of unknown origin

Jacopo C DiFrancesco,Valeria Isella,Daniele Licciardo,Cinzia Crivellaro,Monica Musarra,Luca Guerra,Nicola Salvadori,Elena Chipi,Carmen Calvello,Cinzia Costa,Carlo Ferrarese

Epilepsy & Behavior（2021）

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摘要

•Late-Onset Epilepsy of Unknown origin (LOEU) presents both focal- and focal to bilateral tonic-clonic seizures.•Late-Onset Epilepsy of Unknown origin presents a mild phenotype with a good response to single antiepileptic treatment.•The cognitive profile of LOEU patients can be normal, with focal deficits or multidomain impairment.•In these patients, the application of neurophysiology and metabolic imaging techniques reveals the dysfunction of the temporal lobe.

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关键词

Late-onset epilepsy,Temporal lobe,FDG-PET,EEG,Neuropsychology

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