Relation of Decongestion and Time to Diuretics to Biomarker Changes and Outcomes in Acute Heart Failure

•Prompt initiation of diuretic therapy was not correlated with faster decongestion in acute heart failure.•The timing of decongestion but not diuretics was associated with better biomarker trajectories.•Residual congestion rather than the timing of decongestion or diuretics predicted prognosis.