Catalyst- And Additive-Free Cascade Phosphorylation/Cyclization Of Propargylic Alcohols And R2p(O)Oh

A novel, catalyst- and additive-free cascade phosphorylation/cyclization of readily available 2-propynolphenols with R2P(O)OH (R = aryl, OPh, OBn) was developed for the construction of 2H-chromen-4-yl phosphinates/phosphonates and water as the only byproduct under mild conditions. The reaction was achieved by using R2P(O)OH as acid-promoter, but also as the phosphinate source with the formation of phosphorylation allene intermediate, and followed by 6-endo-trig pathway. Additionally, this approach avoided the use of hazardous, air sensitive or activation reagents, and performed well with good functional group tolerance and satisfied yields. (C) 2021 Elsevier Ltd. All rights reserved.