Acid-Promoted Selective Synthesis Of Trifluoromethylselenolated Benzofurans With Se-(Trifluoromethyl) 4-Methylbenzenesulfonoselenoate

A Bronsted acid-promoted trifluoromethylselenolation of benzofurans was disclosed by using Se-(trifluoromethyl) 4-methylbenzenesulfonoselenoate as a stable and easily prepared electrophilic trifluoromethylselenolating reagent. A wide range of SeCF3-substituted benzofuran derivatives were obtained in moderate to good yields with excellent regioselectivity. The tandem cyclization/trifluoromethylselenolation procedure of 1-methoxy-2-(arylethynyl)benzenes were also realized by engaging FeCl3 as the catalyst. (C) 2021 Elsevier Ltd. All rights reserved.