Gut microbiota dysbiosis in stable coronary artery disease combined with type 2 diabetes mellitus influences cardiovascular prognosis

Ran Tian,Honghong Liu,Siqin Feng,Hui Wang,Yifei Wang,Yiyang Wang,Lifeng Liang,Haopeng Xu,Haiping Xing,Shuyang Zhang

Nutrition, Metabolism and Cardiovascular Diseases（2021）

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摘要

•Significant difference in gut bacteria exists between SCAD and SCAD + T2DM patients.•SCAD + T2DM patients show a different metabolite profile compared to SCAD patients.•Ruminococcus torques is enriched in SCAD + T2DM patients and predicts prognosis.•Metformin treatment alters SCAD + T2DM patients' gut bacteria and metabolite profile.

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关键词

Stable coronary artery disease,Type 2 diabetes mellitus,Metagenomics,Metabolomics,Multi-omics analysis,Cardiovascular prognosis

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