Dose-dependence in acquisition of drug tolerant phenotype and high RYK expression as a mechanism of osimertinib tolerance in lung cancer

Shuta Ohara,Kenichi Suda,Toshio Fujino,Akira Hamada,Takamasa Koga,Masaya Nishino,Masato Chiba,Masaki Shimoji,Toshiki Takemoto,Junichi Soh,Tetsuya Mitsudomi

Lung Cancer（2021）

引用 6|浏览7

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摘要

•The inducibility of drug tolerant cells depended on the type of cell line.•Acquisition of DTC phenotype was a cellular response to high dose of EGFR-TKI.•High expression of RYK was a molecular mechanism of the drug-tolerant state.

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关键词

Molecular targeted therapy,Acquired resistance,Drug-tolerant cells,Osimertinib,Afatinib

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