Urinary Bisphenol A Levels In Prepubertal Children With Exogenous Obesity According To Presence Of Metabolic Syndrome

Objectives: Recent studies have shown a potential link between chronic exposure to Bisphenol A (BPA) and exogenous obesity, the prevalence of which has been increasing dramatically in all age groups and particularly among children in the last decades. In this study, we aimed at comparing BPA exposure levels between controls and otherwise healthy, drug-naive, pre-pubertal children having exogenous obesity with/without metabolic syndrome.Methods: A total of 63 pre-pubertal children with exogenous obesity whom 27 of them having metabolic syndrome attending Hacettepe University Ihsan Dogramaci Children's Hospital were included in this study. The control group consisted of 34 age- and sex-matched healthy children with no significant underlying medical conditions. Urinary BPA levels were measured using LC-MS/MS (high-performance liquid chromatography coupled with tandem mass spectrometry) methodology.Results: Urinary BPA levels among obese children were significantly higher than those of the control group (median: 22.9 mu g/g-creatinine and 6.9 mu g/g-creatinine, respectively; p=0.0001). When adjusted with generalized linear models for age, gender and z scores of body mass index, obese children having metabolic syndrome had significantly higher urinary BPA levels than obese children without metabolic syndrome and both obese groups had considerably elevated levels of urinary BPA than the controls (estimated marginal mean +/- standard error: 42.3 +/- 7.4 mu g/g-creatinine, 22.6 +/- 3.5 mu g/g-creatinine and 12.1 +/- 2.5 mu g/g-creatinine, respectively, p=0.0001)Conclusions: This study shows much higher BPA exposure among obese children with metabolic syndrome during the prepubertal period.