Brahma-Related Gene 1 Inhibition Prevents Liver Fibrosis and Cholangiocarcinoma by Attenuating Progenitor Expansion.

Yongjie Zhou,Yuwei Chen,Xiaoyun Zhang,Qing Xu,Zhenru Wu,Xiaoyue Cao,Mingyang Shao,Yuke Shu,Tao Lv,Changli Lu,Mingjun Xie,Tianfu Wen,Jiayin Yang,Yujun Shi,Hong Bu

Hepatology (Baltimore, Md.)（2021）

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摘要

We have demonstrated the function of Brg1 in promoting HPC expansion, liver cirrhosis, and, ultimately, iCCA development in chronically injured livers, which is largely dependent on Wnt/β-catenin signaling. Our data suggest that therapies targeting Brg1-expressing HPCs are promising for the treatment of liver cirrhosis and iCCA.

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关键词

Brg1,HPC expansion,Wnt/β-catenin signaling,intrahepatic cholangiocarcinoma,liver fibrosis

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