Peroxide- and transition metal-free electrochemical synthesis of α,β-epoxy ketones

A novel electrochemical method for the synthesis of alpha,beta-epoxy ketones is reported. With KI as the redox mediator, methyl ketones reacted with aldehydes under peroxide- and transition metal-free electrolytic conditions and afforded alpha,beta-epoxy ketones in one pot (36 examples, 52-90% yield). This safe and environmental-friendly method has a broad substrate scope and can readily provide a variety of alpha,beta-epoxy ketones in gram-scales for evaluation of their anti-cancer activities.