Biochemical, Cellular, and Proteomic Characterization of Hereditary Spherocytosis Among Tunisians.

Nawel Trabelsi,Ghada Bouguerra,Faten Haddad,Monia Ouederni,Imen Darragi,Imen Boudrigua,Dorra Chaouachi, Mbarka Barmat, Chaker Fouzai,Mohamed Bejaoui,Samia Menif, Imen Kraiem,Salem Abbes

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2021）

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摘要

Our study highlights the efficiency of the EMA dye for the detection of HS whatever the nature of the involved protein deficiency. We report for the first time, the most prevalent protein deficiency among Tunisians with HS. Moreover, we found that the combination of the EMA-binding test with PT or incubated OFT improves the diagnosis sensitivity while maintaining a good specificity.

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关键词

Hereditary Spherocytosis, Band 3 protein, EMA dye, Membrane proteins electrophoresis, Red cell fragility

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