Diagnostic performance of preoperative CT in differentiating between benign and malignant origin of suspicious gallbladder lesions

•Sensitivity of CT for diagnosing gallbladder cancer is high, but specificity is relatively low.•A preoperative CT-based risk score for gallbladder cancer was developed, based on three predictors.•Use of the proposed CT-based risk score may facilitate differentiating between benign and malignant origin of suspicious gallbladder lesions and optimize treatment.