The glutamine antagonist prodrug JHU-083 slows malignant glioma growth and disrupts mTOR signaling.
Neuro-oncology advances（2021）
摘要
Targeting glutamine metabolism with JHU-083 showed efficacy in preclinical models of mut glioma and measurably decreased mTOR signaling.
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关键词
IDH mutation,cell cycle,glioma,glutamine metabolism,mTOR signaling
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