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钠氢交换蛋白1及其抑制剂的研究进展

Jiaqi Ma,Zhangwei Chen,Juying Qian

Chinese Journal of Cardiovascular Medicine（2019）

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Abstract
钠氢交换蛋白1(NHE-1)是一种细胞膜蛋白,主要分布于人和哺乳动物的心肌细胞中,调控细胞内外离子交换.目前越来越多的基础研究证实,NHE-1在多种心血管疾病中,尤其是心力衰竭、心肌肥厚、冠心病等的发生、发展中起着重要作用.虽然近十余年来,多项针对NHE-1抑制剂的临床研究结果差强人意,但我们应从中归纳总结、辩证分析,以期寻找到其真正的临床意义.
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Key words
Sodium hydrogen exchange protein-1,Myocardial reperfusion injury,Myocardial hypertrophy
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