Synthesis And Antifungal Activity Of New Hybrids Thiazolo[4,5-D]Pyrimidines With (1h-1,2,4)Triazole

Svetlana V Blokhina,Angelica V Sharapova,Marina V Ol'khovich,Irina A Doroshenko,Igor B Levshin,German L Perlovich

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2021）

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摘要

Synthesis and antifungal activity of hybrids of thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazoles are presented. The solubility and lipophilicity of compounds was assessed and it was discovered that compounds with piperazine linker exhibited significant antifungal activity against filamentous and yeast fungi.

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关键词

Hybrids, Thiazolo-pyrimidins, Triazole, Lipophilicity, Solubility, Antifungal activity

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