The Evolution of Chest CT Findings from Admission to Follow-Up in 30 Moderate to Severe Adult Patients with COVID-19 Pneumonia.

To analyze the evolution of chest computed tomography (CT) findings from admission to follow-up in moderate to severe patients with coronavirus disease-19 (COVID-19) pneumonia. During December 2019–April 2020, the sequential CT images of 30 patients with COVID-19 pneumonia were retrospectively analyzed from admission to follow-up. The qualitative evolution tendency of lung abnormalities and semi-quantitative CT scores were analyzed for temporal change. The mean hospitalized period was 24.5 ± 9.6 days (range 6–49 days). The average time from the first, second, third, fourth and follow-up CT examination to the initial symptom onset were 4.2 ± 3.1 days, 10.7 ± 4.4 days, 17.1 ± 3.9 days, 24.6 ± 7.5 days, and 42.4 ± 15.6 days, respectively. During illness day 0–5, groundglass opacity (GGO) was the main pattern. The following illness day 6–11, the main CT pattern was consolidation and reticular pattern. The consolidation and reticular pattern gradually dissipate during illness day 12–23, and the reticular pattern and light GGO increased. When illness day was ≥ 24 days, the reticular pattern and light GGO gradually decrease until complete dissipation. The highest CT score was at illness day 6–11. Pearson correlation analysis showed that the mean and maximum CT score were not correlated with the length of fever (r = 0.018, p = 0.923 and r = 0.086, p = 0.652) and hospitalization (r = 0.192, p = 0.31 and r = 0.273, p = 0.144). The dynamic evolution of CT manifestation in moderate to severe COVID-19 pneumonia patients followed a specific pattern over time. During illness day 6–11, the extent of lung abnormalities on chest CT was the most severe.