Efficacy of the LNG-IUS for treatment of endometrial hyperplasia and early stage endometrial cancer: Can biomarkers predict response?

•Endometrial cancer is rising in incidence globally, particularly in younger women.•The intrauterine device may be used to treat early stage endometrial cancer.•Only half of women with endometrial cancer treated with the LNG-IUS will respond.•This review examines potential molecular predictive biomarkers for future research.