Unique structural features of flaviviruses’ capsid proteins: new insights on structure-function relationship

•Atomic-resolution structures of flaviviruses’ C proteins reveal unique structural features.•3D-structure of flaviviruses’ C proteins is predominantly maintained by quaternary contacts.•Long-range effects confer a highly positive electrostatic potential on C proteins surface.•Helix α1 structural flexibility might regulate molecular recognition by flaviviruses’ C proteins.