Suppression Of Insulin-Induced Gene 1 (Insig1) Function Restrains Nash Progression By Promoting Hepatic Lipid Remodelling

Vian Azzu,Michele Vacca,Ioannis Kamzolas,Zoe Hall,Jack Leslie,Stefania Carobbio,Samuel Virtue,Susan Davies,Agnes Lukasic,Martin Dale,Mohammad Bohlooly-Y,Animesh Acharjee,Daniel Linden,Guillaume Bidault,Evangelia Petsalaki,Julian Griffin,Fiona Oakley,Antonio Vidal-Puig,Michael Allison

Molecular Metabolism（2021）

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摘要

•Human NASH biopsies’ transcriptomics analysis features metabolic pathway rewiring.•SCAP/SREBP/INSIG1 modulation promotes lipid/cholesterol synthesis/remodelling in NASH.•Loss of Insig1 promotes lipid remodelling, preventing hepatic lipotoxicity in NASH.•Loss of Insig1 improves liver damage and wound healing and restrains NASH progression.

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关键词

Non-alcoholic fatty liver disease (NAFLD),De novo lipogenesis (DNL),Lipid remodelling,Western diet,Carbon tetrachloride (CCl4),Liver regeneration

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