Pyridine Derivatives of Acridine and Quinoline

A convenient one-pot approach was proposed for the synthesis of new derivatives of 8,9,10,12tetrahydrobenzo[ a ]acridin-11(7 H )-one and 10,12-dihydrobenzo[ f ]pyrimido[4,5- b ]quinoline-9,11(7 H ,8 H )-dione containing residues of nicotinic and isonicotinic acids covalently attached via ester groups in different positions of the aromatic core. Quaternary ammonium salts of the synthesized acridine derivatives as well as a metal complex with palladium PdLCl 2 were obtained. These compounds contain a number of pharmacophore groups so going to be promising potential drugs with antimicrobial, antiviral, and antitumor activity.