rs629301 CELSR2 polymorphism confers a ten-year equivalent risk of critical stenosis assessed by coronary angiography

Davide Noto,Angelo B. Cefalù,Nicola Martinelli,Antonina Giammanco,Rossella Spina,Carlo M. Barbagallo,Marco Caruso,Salvatore Novo,Filippo Sarullo,Vincenzo Pernice,Federica Brucato,Valeria Ingrassia,Francesca Fayer,Grazia I. Altieri,Chiara Scrimali,Gabriella Misiano,Oliviero Olivieri,Domenico Girelli,Maurizio R. Averna

Nutrition, Metabolism and Cardiovascular Diseases（2021）

Cited 7|Views6

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Abstract

•2429 patients subjected to CAG were genotyped for the rs629301 polymorphism.•Critical coronary stenosis was defined as an occlusion >50% of the artery lumen.•Lipids, apolipoproteins and Lp(a) were assayed in the cohort.•The T/T risk genotype was associated with higher levels of lipids, and apolipoproteins.•The independent T/T coronary risk (+43%) equaled the risk of being 10 years older (+39%).

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Key words

Coronary artery disease,Gene polymorphism,Sortilin,Lipids,Apolipoproteins

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