Abstract 15736: The Sphk1/s1p Signaling Axis Regulates Pulmonary Vascular Inflammation by Activating Nf-kb and Nlrp3 Inflammasome

Yang Bai, Alan de Brito Carneiro,Angelia Lockett,Marta T Gomes,Nicole Jones, Yen Chun Lai,Roberto F MacHado

Circulation（2020）

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摘要

Rationale: Pulmonary vascular inflammation is activated during the development of pulmonary arterial hypertension (PAH). Sphingosine kinase 1 (Sphk1) catalyzes the formation of sphingosine-1-phosph...

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