Efficacy & Efficiency Of Genome Editing With Crispr/Cas9 In A Humanized Knock-In Mouse Model Of Plnr14del

Francesca Stillitano,Nour Raad,Zhang Lu,Anthony Fargnoli,Dongtak Jeong,Delaine Ceholski,Erik Kohlbrenner,Jaydev Dave,Cai Chenleng,Fadi Akar,Roger J. Hajjar

Circulation（2018）

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摘要

Introduction: A mutation in the Phospholamban (PLN) gene, a calcium regulating protein, the Arg14 deletion (R14del), has been identified in patients with atypical Arrhythmogenic Cardiomyopathy (ACM...

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genome editing,crispr/cas9,plnr14del

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