A continual reassessment method without undue risk of toxicity

Weijia Zhang,Xikui Wang,Saman Muthukumarana,Po Yang

Communications in Statistics - Simulation and Computation（2021）

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摘要

We revisit our earlier extension of the CRM and introduce a new version of the dose escalation procedure. Its performance is assessed by simulation, with respect to a template of five operating mea...

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关键词

Bayesian method, Continual reassessment method, Dose finding, Maximum tolerated dose, Phase I clinical trials, Toxicity

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