Regioselective assembly of fused pyrazole-azepine heterocycles: Synthesis of the 5-HT7 antagonist 1-benzyl-3-(4-chlorophenyl)-1,4,5,6,7,8-hexahydropyrazolo[3,4-d]azepine

Curt A. Dvorak,Jimmy Liang,Neelakandha S. Mani,Nicholas I. Carruthers

TETRAHEDRON LETTERS（2021）

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摘要

•Selective pyrazole construction.•Regioselective fused azepine-pyrazole assembly.•Pyrazole triflate coupling.•Selective Ring expansion.•Selective 5-HT7 antagonist clinical candidate.

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关键词

Heterocycles,Pyrazole coupling,Pyrazolo[3,4-d]azepine,5-HT7 antagonist

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