Synthesis Of Imidazole And Histidine-Derived Cross-Linkers As Analogues Of Gold And Desmosine
SYNTHESIS-STUTTGART(2021)
摘要
Amino acid derivatives with a central cationic heterocyclic core (e.g., imidazolium) are biologically relevant cross-linkers of proteins and advanced glycation end (AGE) products. Here, imidazolium-containing cross-linkers were synthesized from imidazole or histidine by N-alkylation employing aspartate- and glutamate-derived mesylates as key step. Biological investigations were carried out to probe the biocompatibility of these compounds.
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关键词
amino acid, cross-linker, desmosine, GOLD, biological activity, advanced glycation end-products
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