Integrated Design Strategy for Additively Manufactured Scaffolds in Tissue Engineering

Additive manufacturing technologies allow for the direct fabrication of 3D scaffolds with improved properties for tissue regeneration. In this scenario, design strategies and 3D fiber deposition technique are considered to develop advanced scaffolds with different lay-down patterns, tailored mechanical and biological properties. 3D poly(epsilon-caprolactone) scaffolds are manufactured and surface-modified (i.e., aminolysis). The effect of surface modification on the mechanical and biological performances of the designed 3D scaffolds is assessed.