Ube2i deletion in adipocytes causes lipoatrophy in mice

Aaron R Cox,Natasha Chernis,Kang Ho Kim,Peter M Masschelin,Pradip K Saha,Shawn M Briley,Robert Sharp,Xin Li,Jessica B Felix,Zheng Sun,David D Moore,Stephanie A Pangas,Sean M Hartig

Molecular Metabolism（2021）

引用 7|浏览10

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摘要

•A new mouse model reveals that Ube2i loss in fat cells impacts body composition.•Ube2i fat-specific knockout (Ube2ia-KO) causes fatty liver and hyperinsulinemia.•Ube2ia-KO mice develop metabolic inflexibility and cold intolerance.•Inflammation and caspase activation of cell death occur in Ube2ia-KO adipocytes.

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关键词

Ube2i,Lipodystrophy,Adipose tissue,Lipid metabolism

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