Extravascular lung water and cardiac function assessed by echocardiography in healthy lowlanders during repeated very high-altitude exposure

•Exposure to 5050 m induced a rapid increase in pulmonary artery pressure (PAP) with slight decrease over 6 days of acclimatization.•Extravascular lung water (EVLW) increased during prolonged exposure to 5050 m, despite gradual decrease in PAP, indicating excessive hydrostatic pressure might not be solely responsible for EVLW-development.•Repeated HA-exposure after weeklong break at low altitude had no acclimatization effect on neither EVLW nor PAP.•This may impact workers needing repetitive ascents to altitude.