Controlled Delivery of Slit3 Proteins from Alginate Microbeads Inhibits In Vitro Angiogenesis

•Slit3 regulates angiogenesis and cell proliferation in many types of cancer.•Slit3 delivery via alginate microbeads inhibits cell migration and tube formation.•Alginate microbeads permit delivery of full length Slit3 protein.•Composition of microbead influences Slit3 encapsulation and release.•Sustained release Slit3 may have a therapeutic role in cancer and anti-angiogenesis.