Redirecting macrophage function to sustain their “defender” antitumor activity
Cancer Cell(2021)
摘要
Macrophages are multi-functional innate immune cells that occupy normal or pathologic tissues, including cancer tissues. The importance of macrophage ontogeny and the transcriptional networks underlying their functional diversity are underappreciated in immuno-oncology. Here, we discuss the implications of these fundamental characteristics for therapeutically reprogramming macrophages to sustain their tumoricidal activities.
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