BMP9 promotes methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in non-obese mice by enhancing NF-κB dependent macrophage polarization

Qianqian Jiang,Qi Li,Beibei Liu,Guixin Li, Gabriel Riedemann,Haristi Gaitantzi,Katja Breitkopf-Heinlein,Ajuan Zeng,Huiguo Ding,Keshu Xu

International Immunopharmacology（2021）

引用 11|浏览4

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摘要

•Bone morphogenetic protein 9 (BMP9) promotes MCD diet-induced nonalcoholic steatohepatitis.•BMP9 accelerates inflammation via macrophage M1 polarization.•BMP9 plays a pro-inflammatory role by activating NF-κB pathway.

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关键词

Bone morphogenetic protein 9 (BMP9),Nonalcoholic fatty liver disease (NAFLD),Nonalcoholic steatohepatitis (NASH),Inflammation,NF-κB

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