The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1α inhibition

André L Queiroz,Sarah J Lessard, Amanda T Ouchida,Hygor N Araujo,Dawit A Gonçalves,Dimitrius Santiago P Simões Fróes Guimarães,Bruno G Teodoro,Kawai So,Enilza M Espreafico,Michael F Hirshman,Luciane C Alberici,Isis do Carmo Kettelhut,Laurie J Goodyear,Leonardo R Silveira

Molecular Metabolism（2021）

引用 14|浏览11

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摘要

•MicroRNA miR-696 is expressed under metabolic stress.•miR-696 downregulates Pgc1α in skeletal muscle.•Downregulation of miR-696 increases mitochondrial function.•AMPK-related kinase SNARK, but not AMPK, regulates miR-696 expression in skeletal muscle.•SNARK plays a novel role in mediating mitochondrial function.

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关键词

miR-696,Mitochondrial function,Skeletal muscle,SNARK,Pgc1α

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