Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent
Neurobiology of Learning and Memory（2021）
Abstract
•RasGRF2 KO mice demonstrated impaired contextual fear conditioning.•Impaired CFC was paralleled by decreases in Ras-GTP in hippocampus and pERK in CA1.•CA1 Ras-GRF2 likely mediates fear conditioning in mice via the Ras-ERK pathway.
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Key words
Contextual fear conditioning,RasGRF2,pERK,Ras,Hippocampus,CA1,Rac1
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