Positive association of high-density lipoprotein cholesterol with lumbar and femoral neck bone mineral density in postmenopausal women

•Lipids affect bone metabolism in experimental models.•High-density lipoprotein cholesterol (HDL-C) favors bone accrual in cells and in rodents.•Findings from clinical studies on lipids and bone mineral density are heterogeneous and contradictory.•HDL-C was linked with higher bone mineral density in a homogeneous cohort of postmenopausal women.