Broad Spectrum beta-Lactamase Inhibition by a Thioether Substituted Bicyclic Boronate.

A. Parkova, A. Lucic,A. Krajnc,J. Brem, K. Calvopina,G.W. Langley, McDonough,P. Trapencieris,C.J. Schofield

ACS Infectious Diseases（2020）

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摘要

β-Lactamases comprise the most widely used mode of resistance to β-lactam antibiotics. Cyclic boronates have shown promise as a new class of β-lactamase inhibitor, with pioneering potential to pote...

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