Vulvar squamous cell carcinoma: Comprehensive genomic profiling of HPV(+) versus HPV(–) forms reveals a different set of potentially actionable biomarkers

Objective: Vulvar squamous cell carcinoma (vSCC) is often associated with either detectable high-risk strains of human papillomavirus (HPV) or chronic dystrophic/inflammatory lesions of postmenopausal women. We sought to assess the genomics of a large cohort of aggressive vSCCs, with an aim to identify distinct mutational signatures based on the presence or absence of HPV genome reads.