Regio- and Stereoselective Synthesis of Novel Β-Lactam Engrafted Spiroheterocyclic Hybrids Via One-Pot Three Component Cycloaddition Strategy

Synthesis of structurally fascinating p-lactam tethered spiroheterocyclic hybrids have been achieved with complete regio- and diastereoselectively in excellent yields via a one-pot three component 1,3-dipolar cycloaddition strategy employing azetidin-2-yl-malononitriles as dipolarophiles. The overall transformation generates four stereogenic carbons via the formation of three new bonds in single operation. Structural elucidation of the synthesized compounds was executed by NMR spectroscopic studies and the regio-/stereoselectivity has been ascertained by single crystal X-ray diffraction analysis. (C) 2020 Elsevier Ltd. All rights reserved.