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Sex Differences in Genetic Predictors of Resilience to Alzheimer’s Disease

Alzheimer's & dementia(2020)

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摘要
Identifying genetic factors that provide resilience against the clinical consequences of Alzheimer’s disease (AD) pathology is likely to accelerate the development of novel therapeutics. Sex differences in AD prevalence, neuropathological presentation, and clinical progression suggest that exploring the sex‐specific genetic architecture of resilience to AD may be a critical first step towards the characterization and development of precision interventions.
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