Structure-based Design of a Specific, Homogeneous Luminescence Enzyme Reporter Assay for SARS-CoV-2

Frederic A Fellouse,Shane Miersch,Chao Chen,Stephen W Michnick

Journal of Molecular Biology（2021）

引用 1|浏览11

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摘要

•Structure-based design of a fast, simple and highly specific SARS-CoV-2 reporter.•High specificity assured by two epitope recombinant antibody recognition of Spike antigen.•Reporter created from antibodies coupled to a luciferase fragment complementation assay.•Resulting reporter can detect SARS-CoV-2 pseudo-virus within minutes.

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关键词

recombinant antibodies,SARS CoV-2,spike (S) protein,protein-fragment complementation assay,Gaussia Luciferase

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